Luigina Mollica
Tél. bureau : 514-252-3400 poste 3404
Fax : 514-254-5094
Tél. laboratoire : 514-252-3400 poste 4658
lmollica.hmr@ssss.gouv.qc.ca
Axe de recherche Immunologie-oncologie
Unité de recherche Régulation transcriptionnelle de l’expression génique
Titre
- Professeur adjoint de clinique
FORMATION
- Ph. D. Pathologie 2006 Imperial College London, University of London
- Maîtrise (équivalent) Hématolgie Moléculaire 2004 Imperial College London, University of London
- Postdoctorat Oncologie Médicale 2002 U. de Montréal
- Medical Specialist certificates (two) Internal Medecine and Hematology 2002 Collège des médecins du Québec
- Provincial medical licence Hematology 2002 Collège des médecins du Québec
- Postdoctorat Hématologie 2001 U. de Montréal
- Medical Specialist certificates (three) Medical Oncology, Hematology, & Internal Medicine 2000 Royal College of Physicians and Surgeons of Canada
- Postdoctorat Médecine Interne 1999 U. de Montréal
- Federal medical licence Medicine 1998 Medical council of Canada
- M.D. Médecine 1996 U. de Montréal
DISTINCTIONS ET RÉALISATIONS
- Young investigator award, British Society for Haemostasis and Thrombosis, 2005
- Young investigator award, International Society of Thrombosis and Haemostasis, 2005
- Clinician-Scientist research prize, UdM, 2007
PERSONNEL DE RECHERCHE
- Yves Paquette (assistant de recherche)
INTÉRÊTS DE RECHERCHE
- Étude des mécanismes moléculaires qui contrôlent l'expression des gènes au niveau des cellules endothéliales et des cellules souches hématopoietiques.
PUBLICATIONS CHOISIES
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Lane D and Mollica L. Haemostatic gene polymorphisms in venous and arterial thrombosis. Pathophysiology of Haemostasis and Thrombosis 2002 Sep-Dec;32(5-6):213-5.
Raymond MA, Mollica L, Vigneault N, Désormeaux A, Chan JSD, Filep JG, and Hébert MJ. Blockade of the apoptotic machinery by cyclosporin A redirects cell death towards necrosis in arterial endothelial cells: regulation by reactive oxygen species and cathepsin D. FASEB Journal 2003 Mar;17(3):515-7.
Mollica L and Lane DA. Genetic studies in complex disease. Journal of Thrombosis and Haemostasis 2004 Feb;2(2):342-343.
Crawley JT, Lam JK, Rance JB, Mollica LR, O’Donnell JS and Lane DA. Proteolytic inactivation of ADAMTS13 by thrombin and plasmin. Blood 2005 Feb 1;105(3):1085-93
Mollica L, Preston RJS, Chion AC, Lees SJ, Collins P, Lewis S, and Lane DA. Autoantibodies to thrombin directed against both of its cryptic exosites. British Journal of Haematology 2006 Feb;132(4):487-93.
Almeida AM, Murakami Y, Layton MD, Hillmen P, Sellick GS, Richards S, Patterson S, Kotsianidis I, Mollica L, Crawford DH, Baker A, Ferguson M, Roberts I, Houlston R, Kinoshita, T, and Karadimitris A. Hypomorphic promoter mutation in the mannosyltransferase-encoding PIG-M gene causes inherited glycosylphosphatidyl-inositol deficiency. Nature Medicine 2006 Jul;12(7):846-51.
Mollica LR, Crawley JTB, Liu K, Wells DJ, Rance JB, Follow G, Landry JR, and Lane DA. Role of 5’ enhancer in the regulation of the human endothelial protein C receptor gene. Blood 2006 Aug 15;108(4):1251-9.
D’Angelo G, Mollica L, Hébert, J, Busque L. Clinical Hematology and Fundamentals of Hemostasis. Chapter 20: Myelodysplastic Disorders. Harmening DM, 5th Edidion, Baltimore, 2007
Bolduc V, Chagnon P, Provost S, Dubé MP, Belisle C, Gingras M, Mollica L, and Busque L. No evidence that skewing of X-inactivation patterns is transmitted to offspring in humans. The Journal of Clinical Investigation, 2008 Jan;118(1):333-41
Liste complète des publications du Dr Mollica (PubMed)
INFORMATIONS COMPLEMENTAIRES
Subventions
- Fonds de démarrage, Hôpital Maisonneuve-Rosemont
- Bourse clinicien-chercheur junior 1 (volet fondamental), FRSQ
- Subvention de démarrage, FRSQ
- Bourse de fonctionnement, Banting Research Foundation