Leonard Levin

Tél. bureau : 514-252-3400 poste 4462
Fax : 514-251-7094
Tél. laboratoire : 514-252-3400 poste 7250
leonard.levin@umontreal.ca

Axe de recherche  Santé de la vision
Unité de recherche  Mécanismes pathophysiologiques

Titre 

  • Professeur titulaire
  • Titulaire de la Chaire de recherche du Canada en ophtalmologie et sciences visuelles

FORMATION

  • Ph.D., Harvard University, Department of Neurobiology. Thesis: Immune Functions of Astrocytes; Thesis Advisor: Howard L. Weiner, M.D. (1988).
  • M.D., Harvard Medical School and Harvard-MIT Program in Health Sciences and Technology. (1988).
  • Fellow in Neuro-Ophthalmology (Simmons Lessell and Joseph Rizzo, preceptors), Massachusetts Eye and Ear Infirmary, Boston, MA. (1992)

DISTINCTIONS ET RÉALISATIONS

  • Grass Foundation fellowship (1983)   
  • NATO fellowship for Advanced Study Institute (1984)       
  • Heed Foundation fellowship (1992-93)  
  • National Eye Institute Travel Fellowship (1993)       
  • Rudin Prize paper co-author (1996)       
  • North American Neuro-Ophthalmology Society Young Investigator Award (1997)       
  • Research to Prevent Blindness Dolly Green Special Scholar Award (1997)       
  • Retina Research Foundation Sam and Bertha Brochstein Award (1997)       
  • Japan Society for the Promotion of Science Fellowship (1999)        
  • Retina Research Foundation Marjorie W. Margolin Prize (2003) 
  • Retina Research Foundation Sam and Bertha Brochstein Award (2004)       

PERSONNEL DE RECHERCHE

  • Maria-Magdalena Catrinescu, assistante de recherche
  • Akiyasu Kanamori, post
  • Rachel Beaubien, M.Sc.
  • Wesley Chan, M.Sc. 

INTÉRÊTS DE RECHERCHE

  • Mécanismes de signalisation intracellulaire de la mort des cellules rétiniennes après dommage axonal - Glaucome et autres neuropathies optiques.
  • Neuroprotection des neurones rétiniennes dans la neuropathie optique et la DMLA .
  • Différentiation des cellules souches des cellules rétiniennes ganglionnaires.

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PUBLICATIONS CHOISIES  

Kanamori A, Catrinescu M, Belisle JM, Costantino S, Levin LA. Retrograde and Wallerian axonal degeneration occur synchronously after retinal ganglion cell axotomy. Am J Pathol, in press.

Lieven CJ, Thurber KA Levin EJ, Levin LA. Ordering of neuronal apoptosis signaling: A superoxide burst precedes mitochondrial cytochrome c release in a growth factor deprivation model. Apoptosis, Epub March 13, 2012.

Catrinescu M, Chan W, Mahammed A, Gross Z, Levin LA. Superoxide signaling and cell death in retinal ganglion cell axotomy: Effects of metallocorroles. Exp Eye Res, 97:31-35, 2012.

Kunik D, Dion C, Ozaki T, Levin LA, Costantino S. Laser-based single-axon transection for high-content axon injury and regeneration studies. PLoS ONE, 6: e26832, 2011.

Cordeiro MF, Levin LA. Clinical evidence for neuroprotection in glaucoma. Am J Ophthalmol, 152:715-716, 2011.

Almasieh M, Lieven CJ, Levin LA, Di Polo A. A cell-permeable phosphine-borane complex delays retinal ganglion cell death after axonal injury through activation of the pro-survival ERK1/2 pathway. J Neurochem, 118:1075-1086, 2011.

Volpe NJ, Levin LA. How should patients with indirect traumatic optic neuropathy be treated?. J Neuro-Ophthalmol, 31:169-174, 2011.

Kanamori A, Catrinescu M, Kanamori N, Mears KA, Beaubien R, Levin LA. Superoxide is an associated signal for apoptosis in axonal injury. Brain, 133:2612–2625, 2010.

Kanamori A, Catrinescu M, Mahammed A, Gross Z, Levin LA Neuroprotection against superoxide anion radical by metallocorroles in cellular and murine models of optic neuropathy. J Neurochem, 114:488-498, 2010.

Nork TM, Kim CBY, Heatley GA, Kaufman PL, Lucarelli MJ, Levin LA, Ver Hoeve JN. Serial multifocal electroretinograms during long-term elevation and reduction of intraocular pressure in non-human primates. Doc Ophthalmol, 120:273–289, 2010.

Levin LA, Danesh-Meyer HV. Lost in translation: Bumps in the road between bench and bedside. JAMA, 303:1533-1534, 2010.

Kern TS, Du Y, Miller CM, Hatala DA, Levin LA. Overexpression of bcl-2 in vascular endothelium inhibits the microvascular lesions of diabetic retinopathy. Am J Pathol, 176:2550-2558, 2010.

Kanamori A, Catrinescu M, Beaubien R, Traistaru M, Levin LA. In vivo imaging of retinal ganglion cell axons within the nerve fiber layer. Invest Ophthalmol Vis Sci, 51:2011-2018, 2010.

Liste complète des publications du Dr Levin (PubMed)

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INFORMATIONS COMPLEMENTAIRES

Collaborations

  •  Adriana DiPolo, Université de Montréal
  • Santiago Costantino, Ph.D.

Subventions

  • Chaire de recherche du Canada en ophtalmologie et sciences visuelles
  • IRSC
  • National Eye Institute (E.U.)
  • FCI

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