Leonard Levin

Titre 

• Professeur titulaire
• Titulaire de la Chaire de recherche du Canada en ophtalmologie et sciences visuelles

FORMATION

• Ph.D., Harvard University, Department of Neurobiology. Thesis: Immune Functions of Astrocytes; Thesis Advisor: Howard L. Weiner, M.D. (1988).
• M.D., Harvard Medical School and Harvard-MIT Program in Health Sciences and Technology. (1988).
• Fellow in Neuro-Ophthalmology (Simmons Lessell and Joseph Rizzo, preceptors), Massachusetts Eye and Ear Infirmary, Boston, MA. (1992)

DISTINCTIONS ET RÉALISATIONS

• Grass Foundation fellowship (1983)   
• NATO fellowship for Advanced Study Institute (1984)       
• Heed Foundation fellowship (1992-93)  
• National Eye Institute Travel Fellowship (1993)       
• Rudin Prize paper co-author (1996)       
• North American Neuro-Ophthalmology Society Young Investigator Award (1997)       
• Research to Prevent Blindness Dolly Green Special Scholar Award (1997)       
• Retina Research Foundation Sam and Bertha Brochstein Award (1997)       
• Japan Society for the Promotion of Science Fellowship (1999)        
• Retina Research Foundation Marjorie W. Margolin Prize (2003) 
• Retina Research Foundation Sam and Bertha Brochstein Award (2004)       

PERSONNEL DE RECHERCHE

• Maria-Magdalena Catrinescu, assistante de recherche
• Akiyasu Kanamori, post
• Rachel Beaubien, M.Sc.
• Wesley Chan, M.Sc. 

INTÉRÊTS DE RECHERCHE

• Mécanismes de signalisation intracellulaire de la mort des cellules rétiniennes après dommage axonal - Glaucome et autres neuropathies optiques.
• Neuroprotection des neurones rétiniennes dans la neuropathie optique et la DMLA .
• Différentiation des cellules souches des cellules rétiniennes ganglionnaires.

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PUBLICATIONS CHOISIES  

Kanamori A, Catrinescu M, Beaubien R, Traistaru M, Levin LA. In vivo imaging of retinal ganglion cell axons within the nerve fiber layer. Invest Ophthalmol Vis Sci, published online September 24, 2009.

Scott CJ, Seidler EA, Levin LA. Cell-autonomous generation of mitochondrial superoxide is a signal for cell death in differentiated neuronal precursor cells. Brain Res, published online October 9, 2009.

Seidler EA, Lieven CJ, Thompson AF, Levin LA. Effectiveness of novel borane-phosphine complexes in inhibiting cell death depends on the source of superoxide production induced by blockade of mitochondrial electron transport. ACS Chem Neurosci, published online November 17, 2009.

Jansonius NM, Nevalainen J, Selig B, Zangwill LM, Sample PA, Budde WM, Jonas JB, Lagréze WA, Airaksinen PJ, Vonthein R, Levin LA, Paetzold J, Schiefer U. A mathematical description of nerve fiber trajectories and their variability in the human retina. Vision Res, 49:2157-2163, 2009.

Hoegger MJ, Lieven CJ, Levin LA. Differential production of superoxide by neuronal mitochondria. BMC Neurosci, 9:4, 2008.

Levin LA, Danesh-Meyer H. Hypothesis: A venous etiology for nonarteritic anterior ischemic optic neuropathy. Arch Ophthalmol, 126:1582-1585, 2008.

Schwechter BR, Millet LE, Levin LA. Histone deacetylase inhibition-mediated differentiation of RGC-5 cells and interaction with survival. Invest Ophthalmol Vis Sci 48:2845-2857, 2007.

Lieven CJ, Millet LE, Hoegger MJ, Levin LA. Induction of axon and dendrite formation during early RGC-5 cell differentiation. Exp Eye Res 85:678-683, 2007.

Levin LA. Mechanisms of retinal ganglion specific-cell death in Leber's hereditary optic neuropathy. Trans Am Ophthalmol Soc, 105:379-391, 2007.

Vrabec JP, Levin LA. The neurobiology of cell death in glaucoma. Eye, 21:S11-14, 2007.

Liste complète des publications du Dr Levin (PubMed)

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INFORMATIONS COMPLEMENTAIRES

Collaborations

•  Adriana DiPolo, Université de Montréal
• Santiago Costantino, Ph.D.

Subventions

• Chaire de recherche du Canada en ophtalmologie et sciences visuelles
• IRSC
• National Eye Institute (E.U.)
• FCI

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