Édouard Kouassi

Titre

• Pharmacien
• Chercheur agrégé

FORMATION

• B.Sc. Pharmacie, UdeM, 1979
• M.Sc. Pharmacologie, UdeM 1981 (Superviseur: Dr. Gilles Caillé)
• Diplôme d'études approfondies (DEA), Immunopharmacologie et Immunotoxicologie, Université Claude-Bernard, Lyon, France, 1982 (Superviseur: Dr. Louis Léry)
• Ph.D. Pharmacologie, UdeM, 1985 (Superviseurs: Dr. Gilles Caillé et Dr. Louis Léry)
• Doctorat d'État ès-Sciences Pharmaceutiques, Université Claude-Bernard, Lyon, France, 1990 (Superviseur: Professeur Jean-Pierre Revillard)
• Stage postdoctoral en Immunologie, INSERM U80, Lyon, France, 1985-1990 (Superviseur: Professeur Jean-Pierre Revillard)

INTÉRÊTS DE RECHERCHE

Bases moléculaires des relations entre le cerveau et l’immunité : implications thérapeutiques dans les maladies neuro-inflammatoires et neuropsychiatriques.

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 PERSONNEL DE RECHERCHE

 Étudiants gradués

• Marie-Ève Koué
• Raouf Igé
• Ingrid Agbato

Stagiaire pré-gradué

• Nancy Zaour

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DISTINCTIONS ET RÉALISATIONS

Chercheur-boursier, programme conjoint du Conseil de recherches médicales du Canada (CRM) et de l’Association Canadienne de l’Industrie du Médicament (ACIM), 1992-1997.

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PUBLICATIONS CHOISIES

Potvin S., Stip E, Sepehry A.A., Gendron A., Bah R., Kouassi E. Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review. Biological Psychiatry (In press).

Landau A.M., Luk K.C., Jones M.L., Siegrist-Johnstone R., Young Y.K., Kouassi E., Rymar V.V., Dagher A., Sadikot A.F., and Desbarats J. Defective Fas expression exacerbates neurotoxicity in a model of Parkinson's disease. The Journal of Experimental Medicine 202: 575-581, 2005.

Abdouh M., Albert P.R., Drobetsky E., Filep J.G., and Kouassi E. 5-HT1A-mediated promotion of mitogen-activated T and B cell survival and proliferation is associated with increased translocation of NF-kappaB to nucleus. Brain, Behavior, and Immunity, 18 : 24-34, 2004.

Gendron A., Kouassi E., Nuara S., Cossette C., D'angelo G., Geadah D., du Souich P., and Teitelbaum J. Transient middle cerebral artery occlusion influence on systemic oxygen homeostasis and erythropoiesis in Wistar rats. Stroke 35: 1979-1984, 2004.

Gendron A., Teitelbaum J., Cossette C., Nuara S., Dumont M., du Souich P., Geadah D., and Kouassi E. Temporal effects of left versus right middle cerebral artery occlusion on spleen lymphocyte subsets and mitogenic responses in Wistar rats. Brain Research 955: 85-97, 2002.

Moisan E., Arbour S., Nguyen N., Hébert M.J., Girard D., Bernier J., Fournier M., and Kouassi E. Prolongation of human neutrophil survival by low-level mercury via inhibition of spontaneous apoptosis. Journal of Toxicology and Environmental Health, Part A, 65: 183-203, 2002.

Abdouh M., Storring J.M., Riad M., Paquette Y., Albert P.R., Drobetsky E., and Kouassi E. Transcriptional mechanisms for induction of 5-HT1A receptor mRNA and protein in activated B and T lymphocytes. Journal of Biological Chemistry 276: 4382-4388, 2001.

Goulet A.C., Goldmacher V.S., Lambert J.M., Roy D.C., Baron C., and Kouassi E. Conjugation of blocked ricin to an anti-CD19 monoclonal antibody increases antibody-induced cell calcium mobilization and CD19 internalization. Blood 90: 2364-2375, 1997.

Kouassi E., and Revillard J.P. Contribution of ß-adrenoceptors to the dopamine-induced elevation of cyclic 3'5'-adenosine monophosphate levels in mouse lymphocytes. Eur. J. Pharmacol. 144: 97-100, 1987.

Kouassi E., Caillé G., Léry L., Larivière L., and Vézina M. Novel assay and pharmacokinetics of levamisole and p-hydroxylevamisole in human plasma and urine. Biopharm. Drug Disp. 7: 71-89, 1986.

Liste complète des publications du Dr Kouassi (PubMed)

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INFORMATIONS COMPLÉMENTAIRES

Fonds AstraZeneca, Research Program in Mental Health and Addiction.