Passer au contenu principal

Lambert Busque

Busque, Lambert

Full professor

Affiliation

Université de Montréal

Research Axes

Immunology-oncology

Contact information

Phone: 514-252-3400, poste4674

lbusque.hmr@ssss.gouv.qc.ca

Team

  • Sammy Ayachi
  • Vincent Bourgoin
  • Manuel Buscarlet

Dr. Lambert Busque is a hematologist and the director of the Clinical Laboratory for Molecular Diagnosis and the Hematopoiesis and Aging Research Unit. He is also a full professor in the Faculty of Medicine at Université de Montréal.

Research Unit

Hematopoiesis and Aging

Research interests

  • Genetic mapping and positional cloning to identify the loci affecting telomere length in blood cells.
  • Identification of quantitative trait loci (QTL) associated with blood cell production.
  • Role of causal mutations of myeloproliferative syndromes (JAK2) in telomere biology.
  • Jamal R., Bélisle C., Lessard M.-C., Hébert J., Roy D.-C., Levine R., Busque L. Evidence suggesting the presence of a stem cell clone anteceding the acquisition of the JAK2-V617F mutation. Leukemia. 2008 Jan 31.
  • Bolduc V., Chagnon P., Provost S., Dubé M.-P., Belisle C., Gingras M., Mollica L., Busque L. No evidence that skewing of X chromosome inactivation patterns is transmitted to offspring in humans. J Clin Invest. 2008 Jan;118(1):333-41.
  • Chagnon P., Schneider R., Hébert J., Fortin P.-R., Provost S., Belisle C., Gingras M., Bolduc V., Perreault C., Silverman E., Busque L. Identification and characterization of an Xp22.33;Yp11.2 translocation causing a triplication of several genes of the pseudoautosomal region 1 in an XX male patient with severe systemic lupus erythematosus. Arthritis Rheum. 2006 Apr;54(4):1270-8.
  • Levine R.-L., Belisle C., Wadleigh M., Zahrieh D., Lee S., Chagnon P., Gilliland D.-G., Busque L. X-inactivation-based clonality analysis and quantitative JAK2V617F assessment reveal a strong association between clonality and JAK2V617F in PV but not ET/MMM, and identifies a subset of JAK2V617F-negative ET and MMM patients with clonal hematopoiesis. Blood. 2006 May 15;107(10):4139-41. Epub 2006 Jan 24.
  • Chagnon P., Provost S., Belisle C., Bolduc V., Gingras M., Busque L. Age-associated skewing of X-inactivation ratios of blood cells in normal females: a candidate-gene analysis approach. Exp Hematol. 2005 Oct;33(10):1209-14.

Education

  • Doctor of Medicine (hematology and molecular biology)

    Harvard University