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Janos Filep

Filep, Janos

Full professor

Affiliation

Université de Montréal

Research Axes

Immunology-oncology

Contact information

Phone: 514-252-3400, poste4662

janos.g.filep@umontreal.ca

patho.umontreal.ca/jgfilepB.htm

Team

  • Amira Othman
  • Meriem Sekheri

Dr. Janos G. Filep (MD, PhD) heads the Innate Immunology and Vascular Immunology Research Unit. He is also a full professor in the Department of Pathology and Cellular Biology at Université de Montréal.

His extensive expertise covers vascular immunology/inflammation (with a focus on leukocyte and endothelial cell pathophysiology), the regulation of the activation of anti-inflammatory cells, and cardiovascular disease. His research is recognized for contributing to the concept of active inflammation resolution and for identifying the mediators, mechanisms and control points that govern this process.

Research Unit

Innate Immunology and Vascular Immunology

Research interests

  • Vascular immunology, inflammation
  • Leukocytes and biology of the endothelial cell
  • Interactions between leukocytes and endothelial cells
  • Oxidative and peroxidative stress (peroxynitrite) and signalling
  • Endogenous anti-inflammatory molecules (aspirin-triggered lipoxins, antiflammins, annexin-1, etc.)
  • Apoptosis
  • Toll-like receptor signalling
  • Cardiovascular disease (coronary artery disease, septic shock)
  • Diabetic nephropathy
  • Zouki C, Beauchamp M, Baron C, Filep JG. Prevention of in vitro neutrophil adhesion to endothelial cells through shedding of L-selectin by C-reactive protein and peptides derived from C-reactive protein. J. Clin. Invest. 100:522-529, 1997.
  • József L, Zouki C, Petasis NA, Serhan CN, Filep JG. Lipoxin A4 and aspirin-triggered 15-epi-LXA4 inhibit peroxynitrite formation, NF-κB and AP-1 activation, and IL-8 gene expression in human leukocytes. Proc. Natl. Acad. Sci. USA, 99:13266-13271, 2002.
  • Khreiss T, József L, Potempa LA, Filep JG. Conformational rearrangement in C-reactive protein is required for proinflammatory actions on human endothelial cells. Circulation 109:2016-2022, 2004.
  • Khreiss T, József L, Potempa LA, Filep JG. Loss of pentameric symmetry in C-reactive protein induces interleukin-8 secretion through peroxynitrite signaling in human neutrophils. Circ. Res., 97:690-697, 2005.
  • El Kebir D, József L, Pan W, Filep JG. Myeloperoxidase delays neutrophil apoptosis through CD11b/CD18 integrins and prolongs inflammation. Circ Res 103:352-359, 2008.
  • El Kebir D, József L, Pan W, Wang L, Petasis NA, Serhan CN, Filep JG. 15-epi-lipoxin A4 inhibits myeloperoxidase signalling and enhances resolution of acute lung injury. Am J Respir Crit Care Med 180:311-319, 2009.
  • El Kebir D, Gjorstrup P, Filep JG. Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation. Proc Natl Acad Sci USA 109:14983-14988, 2012.
  • Filep JG. Biasing the lipoxin A4/formyl peptide receptor 2 pushes inflammatory resolution. Proc Natl Acad Sci USA 110:18033-18034, 2013.
  • El Kebir D, Damlaj A, Makhezer N, Filep JG. Toll-like receptor 9 signaling regulates tissue factor and tissue factor pathway inhibitor expression in human endothelial cells and coagulation in mice. Crit Care Med 43:e179-e189, 2015.
  • El Kebir D, de Oliveira Lima dos Santos E, Mansouri S, Sekheri M, Filep JG. Mild acidosis delays neutrophil apoptosis via multiple signaling pathways and acts in concert with inflammatory mediators. J Leukoc Biol, 102:1289-1400, 2017.

Education

  • Postdoctoral fellowship in immunology

    Université de Montréal

  • Postdoctoral fellowship in pharmacology

    Université de Sherbrooke

  • Postdoctoral fellowship in pharmacology

    Medizinische Hochschule Hannover, FRG

  • Research fellow in pharmacology and clinical pharmacology

    Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany

  • Research fellow in physiology

    Semmelweis University Medical School

  • Isotope medicine

    Postgraduate medical studies, Budapest

  • Blood Transfusion Medicine

    Postgraduate Medical School, Budapest

  • Doctor of Medicine

    Semmelweis University Medical School

  • MSc (equivalent) in physiology

    Semmelweis University Medical School

Awards

  • 2010 Member of the Scientific Steering Committee  (International Academy of Cardiology)
  • 2010 Gold Medal for Canada  (American Biographical Institute)
  • 2007 Member, Scientific Committee  (International Academy of Cardiology, USA)
  • 2009 Recognition  (Presidential Who's Who, Long Island City, NY)
  • 2004 Recognized as one of the “2000 outstanding intellectuals of the 21st Century”  (International Biographical Centre, Cambridge)
  • 2004 Recognized as one of the “Great minds of the 21st Century” in  (American Biographical Institute)
  • 2003 Medal for Science and Peace  (Albert Schweitzer International University, Genève)
  • 2000 Honorary professor  (Albert Schweitzer International University, Genève)
  • 1993 Senior 2 Research Scholar  (FRSQ)
  • 1989 Postdoctoral fellowship  (Medical Research Council of Canada)