Passer au contenu principal

Éric Milot

Milot, Éric

Full professor

Affiliation

Université de Montréal

Research Axes

Immunology-oncology

Contact information

Phone: 514-252-3551

e.milot.1@umontreal.ca

Team

  • Stefania Bottardi
  • Anaïs Darracq
  • Eliza Eskafi Sabet

With a PhD in molecular biology, Éric Milot oversees the Malignant Hematopoiesis and Epigenetic Regulation of Gene Expression Research Unit. Éric Milot is also a full professor in the Department of Biochemistry and Molecular Medicine at Université de Montréal.

His research focuses on malignant hematopoiesis and the epigenetic regulation of gene expression. Éric Milot also contributes to the advancement of research as a member of several scientific review committees for various agencies, including the CIHR, FRQS and NSERC. He is a member of the genetics section of the CIHR’s College of Reviewers.

Research Unit

Malignant Hematopoiesis and Epigenetic Regulation of Gene Expression

This research unit studies the mechanisms of epigenetic regulation of gene expression during hematopoiesis:

  • Identification of the molecular factors and mechanisms involved in epigenetic programming and regulation of gene expression.
  • The team uses genetically modified mice, embryonic stem cells and human hematopoietic cells in their research.

Another focus is the characterization of factors that promote leukemia development. In this area, the team is studying how certain factors influence cell proliferation regulation pathways and cell death.

  • Bottardi S., Guieze R., Bourgoin V., Fotouhi-Ardakani N., Darracq A., Abdelali Lakehal Y., Dougé A., Berger MG., Mollica L., Bay JO., Omichinsky JG., Milot E., 2020, MNDA controls the expression of MCL-1 and BCL-2 in chronic lymphocytic leukemia cells. Exp Hematol. 88:68-82.e5. doi: 10.1016/j.exphem.2020.07.004. Epub 2020 Jul 16.
    More detail
  • Sen Nkwe N., Daou S., Uriarte M., Gagnon J., Iannantuono NV., Barbour H., Yu H., Masclef L., Fernandez E., Zamorano Cuervo N., Mashtalir N., Binan L., Sergeev M., Belanger F., Drobetsky E., Milot E., Wurtele H., Costantino S., and Affar EB., 2020 A potent nuclear export mechanism imposes USP16 cytoplasmic localization and indirect regulation of DNA double strand break repair. Journal of Cell Science, Feb 24;133(4): jcs239236. doi: 10.1242/jcs.239236
    More detail
  • Darracq A., Pak H., Bourgoin V., Dellaire G., Affar EB., Milot E., 2019. NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes. PLOS Genet. 1;15(11): e1008463. doi: 10.1371/journal.pgen.1008463. eCollection 2019 Nov.
    More detail
  • Daou S, Hammond-Martel I, Mashtalir N, Barbour H, Gagnon J, Iannantuono NV, Sen Nkwe N, Motorina A, Pak H, Yu H, Wurtele H, Milot E, Mallette FA, Carbone M, Affar EB. 2015. The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and is Disrupted in Cancer. J. Biol. Chem. 290(48):28643-63.
    More detail
  • Bottardi S., Mavoungou L., and Milot E. 2015. IKAROS: a multifunctional regulator of the polymerase II transcription cycle. Trends Genet. 31(9):500-8.
    More detail
  • Bottardi S., Mavoungou L., Pak H., Daou S., Bourgoin V., Lakehal, YA., Affar EB. and Milot E. 2014. The IKAROS Interaction with a Complex Including Chromatin Remodeling and Transcription Elongation Activities Is Required for Hematopoiesis, PLoS Genet. 10(12): e1004827.
    More detail
  • Bottardi S., Mavoungou L., Bourgoin V., Mashtalir, N., Affar, EB. and Milot E. 2013. Ikaros-CDK9 interplay direct protein interactions are responsible for Ikaros-GATA and Ikaros-CDK9 cooperativity in hematopoietic cells, Mol. Cell. Biol. 33(16):3064-76.
  • Milot E., Fotouhi-Ardakani N. and Filep J.G. 2012 Myeloid nuclear differentiation antigen, neutrophil apoptosis and sepsis. Frontiers in Immunology. 3:397. doi: 10.3389/fimmu.2012.00397
    More detail
  • Ross J., Mavoungou L., Bresnick E. and Milot E. 2012. GATA-1 utilizes Ikaros and the Polycomb Repressive Complex 2 to suppress Hes1 and to promote erythropoiesis. Mol. Cell. Biol. 32(18):3624-38.
    More detail
  • Milot E. and Filep J.G. Regulation of neutrophil survival/apoptosis by Mcl-1. The Scientific WorldJOURNAL; 11:1948-62
    More detail
  • Bottardi S., Zmiri F.A., Bourgoin V., Ross J., Mavoungou L., Milot E. 2011. Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongation. Nucleic Acids Res. 39(9):3505-19.
    More detail
  • Fotouhi-Ardakani N., El Kebir D., Pierre-Charles N., Wang L., Ahern S.P., Filep J.G. and Milot E. 2010. Role for Myeloid Nuclear Differentiation Antigen in the Regulation of Neutrophil Apoptosis during Sepsis. Am. J. Resp. Crit. Care Med. 182(3), 341-50.
    More detail
  • Ross J., Bottardi S., Bourgoin V., Wollenschlaeger A., Drobetsky E., Trudel M. and Milot E. 2009. Differential requirement of a distal regulatory region for pre-initiation complex formation at globin gene promoters. Nucl. Acids Res. 37(16), 5295-5308.
    More detail

Education

  • Postdoctoral fellowship in cell biology and genetics

    Erasmus University Rotterdam, the Netherlands

  • PhD in molecular biology

    Université de Montréal

  • BSc in biology

    Université de Sherbrooke

Awards

  • 2010 Senior Research Scholar  (FRQS)
  • 2007 Junior 2 Research Scholar  (FRQS)
  • 2002 New Investigator Award  (CIHR)
  • 2000 Junior 1 Research Scholar  (FRQS)