Martin Guimond has a PhD in biomedical sciences (immunology-oncology) and is the head of the Immunoregulation Research Unit. His work is mainly in the area of cellular therapy. He is also a professor and assistant researcher in the Department of Microbiology, Infectious Diseases and Immunology at Université de Montréal.
Martin Guimond completed a postdoctoral fellowship at the National Cancer Institute, a division of the prestigious National Institutes of Health. His work has been published in the renowned scientific journal Nature Immunology. He has explained how the immune system of AIDS patients and transplant recipients can regenerate and demonstrated the cause of immune cell death in AIDS patients and transplant recipients.
Our goal is to better understand the fundamental processes that interfere with and regulate the regeneration of naive CD4+ T cells in human lymphocytopenia to improve their recovery and increase the effectiveness of immunotherapy. Our researchers use their clinical expertise to develop mouse models that recreate human conditions.
Our unit has two main research projects: the biology and therapy of cell depletion and the immunobiology and immunotherapy of graft-versus-host disease (GVHD).
Biology and therapy of cell depletion
The specific objectives of Project 1 are as follows:
- Identify how a high level of IL-7 observed in lymphocytopenia can impair the ability of antigen-presenting cells (APC) to support the HPE of CD4-naive cells.
- Identify the differential requirements of HPE of non-regulatory CD4+CD25- T cells versus regulatory CD4+CD25+ T cells, with an emphasis on the role of IL-7 from APC in these two populations.
- Identify how IL-7 therapy can lead to the expansion of naive CD4 T cells.
Immunobiology and immunotherapy of graft-versus-host disease
The translation-to-clinic aspect of our work focuses on transplant patients. The specific goals of Project 2 are therefore to understand the immunobiology of allogeneic transplants and the effect of GVHD on lymphocyte regeneration and homeostasis:
- Identify how GVHD affects the ability of IL-7Rα+ DCs to support CD4 HPE.
- Improve immune reconstitution during GVHD.
Our goal is to help develop IL-7 as a more effective immune system stimulant compared to IL-2 and to find a role for this cytokine in cancer immunotherapy in both lymphopenic hosts and hosts with normal T-cell levels.
PublicationsVoir toutes les publications
Shriner AK*., Sun G*., Guimond M., Allugupalli KR. Interleukin-7-driven B1b lymphopoiesis is critical for T cell-independent antigen responses and protective immunity (*co-first author), J Immunol. 2010 Jul 1;185(1):525-31.
Krauss A*.,Fewkes N*.,Guimond M., Dobre S., Mackall, CL.: Transient, Pharmacologic Modulation of Niche Accessibility via Tyrosine Kinase Inhibition Enhances Engraftment Following Hematopoietic Stem Cell Transplantation. (*co-first author), Blood. 2010 May 20;115(20):4120-9.
Guimond M., Freud A.G., Mao HC, Bradley B.W., Leong J.W., Vandeusen J.B., Dorrance A., Mackall C.L., Caligiuri M.A.: The invivo role of dendritic cells in natural killer cell homeostasis and expansion. J. Immunol. 2010 Mar 15;184(6):2769-75.
Cui Y., Zhang H., Meadors, J., Poon R., Guimond M., Mackall CL: Harnessing the physiology of lymphopenia to support Adoptive immunotherapy in lymphoreplete hosts. Blood. 2009 Oct 29;114(18):3831-40
Guimond M., Grindler D., Graham R., Polly Matzinger, P., Merchant MS., Mackall CL.: IL-7 signaling on IL-7RαDCs regulates the naïve CD4 niche controlling homeostatic peripheral expansion. Nat Immunol. 2009 Feb;10(2):149-57.
Guimond M., Veenstra RG., Grindler DJ., Hua Z., Cui Y., Murphy RD., Kim,SY., Na, R., Henninghausen L., Kurtulus S., Erman B., Matzinger P., Merchant, MS., Mackall CL. IL-7 Signaling on IL-7R?DCs Regulates the Naïve CD4 Niche Controlling Homeostatic Peripheral Expansion. Nat Immunol. 2009 Feb;10(2):149-57.
Reddy, O., Arora, M., Guimond, M., Mackall, CL. GVHD: A Continuing Barrier to the Safety of Allogeneic Transplantation. Biol Blood Marrow Transplant :1-7, November 2008
Dorrance AM., Liu S., Chong A., Pulley B., Guimond M., Yuan W., Chang D., Susan P. Whitman SP., Marcucci G., Caligiuri MA An in vivo analysis of the Mll partial tandem duplication reveals alterations that are dependent and independent of the Mll wild type allele. Blood. 2008 Jul 10. (Epub ahead of print)
Guimond M., Leonard WJ., Rossi SW., Veenstra R.G., Hollander GA., Mackall CL., Blazar BR. Thymic Stromal Lymphopoietin (TSLP) Is Not Necessary or Sufficient to Mediate the Thymopoietic Effects of Keratinocyte Growth Factor (KGF). Blood, 15 January 2008, Vol. 111, No. 2, pp. 969-70.
Opavsky R., Tsai SY., Guimond M., Arora A, Opavska J., Trikha P., Maiti B., Wu L., Becknell B., Kaufmann M., Walton N., Stephens JA., Fernandez SA., Muthusamy N., Felsher DW., Altura R., Caligiuri MA., Leone G. Specific tumor suppressor function for E2F2 in Myc-induced T cell lymphomagenesis. Proc Natl Acad Sci U S A. 2007 Sep 19.
Postdoctoral fellowship with Crystal L. Mackall in Pediatric Hematology & Oncology, Immunology Section
National Institutes of Health, National Cancer Institute
Postdoctoral fellowship with Michael A. Caligiuri, Immunology Section
Ohio State University
PhD in biomedical sciences, immunology-oncology
Université de Montréal
MSc in microbiology and immunology
Université de Montréal
BSc in microbiology and immunology
Université de Montréal
- Best Cytokine Paper Award (National Institutes of Health, National Cancer Institute)
- 2008 Junior Research Scholar (FRSQ)
- 2007 Travel Award (American Society of Hematology)
- 2006 NCI Merit Award (NIH/NCI)
- 2005 NCI Merit Award (NIH/NCI)
- 2004 Postdoctoral Visiting Fellow Award (National NIH/NCI)
- 2001 Up on the roof fellowship award (Columbus, OH, USA)
- 2001 PhD with high distinction (Université de Montréal)
- 2000 First prize for an oral presentation (7th Annual Meeting of the Canadian Blood and Marrow Transplant Group)