Przemyslaw (Mike) Sapieha
Office Phone: 514-252-3400 ext. 7711
Lab Phone: 514-252-3400 ext. 7716
Research Axis Vision Health
Research Unit Neuro-vascular Ocular Diseases
- Assistant Professor
- Postdoctorate, 2008-2010, Harvard Medical School
- Postdoctorate, 2006-2008, McGill University
- Ph.D., 2002-2005, Université de Montréal
DISTINCTIONS AND ACHIEVEMENTS
- Canada Research Chair in Retinal Cell Biology 2010-
- Canadian National Institute for the Blind New Researcher Award 2010
- Charles A King Trust Postdoctoral Fellowship, 2009-2011
- CIHR Postdoctotal Fellowship, 2009-2010
- Foundation of Stars, Award of Excellence in Pediatric Research 2008
- Fondation de la Recherche sur les Maladies Infantiles Postdoctoral Scholarship 2008
- Heart and Stroke Foundation of Canada Research Fellowship Award 2006-2008
- J.A. De Sève Award 2005
- Alcon Young Investigator Award 2012
Angiogenesis (the generation of new blood vessels from pre-existing ones) is a highly synchronized process requiring the coordinated efforts of several vascular and non-vascular cell populations and a stringent orchestration by the tissue being vascularized. Stereotyped angiogenesis is vital for both developmental growth and to restore tissue oxygenation and metabolic supply following vascular injury.
Given that angiogenesis becomes deregulated in numerous pathological contexts such as cancer and ischemic neuropathies, it is key to understand the molecular and cellular mechanism that ensure sound vessel growth. Our laboratory studies angiogenesis with a focus on ocular vascular systems. We tackle these diseases by studying vascular growth and the factors that regulate it. Moreover, we are interested in the cellular interactions and intracellular mechanisms that govern vessel growth in both physiological and pathological contexts.
- Éric Lapalme, Lab Manager
- Sullivan Henriques, Technicien
- Patricia A. Martínez Barrios, Technicien (co-supervised with Dr. Costantino)
- Agnieszka Dejda, Postdoctoral Fellow
- Khalil Miloudi, Postdoctoral Fellow
- Malika Oubaha, Postdoctoral Fellow
- Zhuo Shao, Postdoctoral Fellow
- Flavio Rezende, Associate Clinical Professor (Postdoctoral Fellow)
- Nicholas James Sitaras, PhD Student (co-supervised with Dr. Chemtob)
- Catherine Ménard PhD Student
- Weimeng Ding, PhD Student (Co-supervised with Dr. Meunier)
- Naoufal Akla PhD Student
- Agustin Cerani, M.Sc. Student
- Gaelle Mawambo, M.Sc. Student
Agustin Cerani, Nicolas Tetreault, Francois Binet, Flavio Rezende, Nicholas Sitaras, Eric Lapalme, Khalil Miloudi, Przemyslaw Sapieha. Neuronal-derived Semaphorin 3A Promotes Vascular Leakage in Diabetic Retinopathy. Cell Metabolism, October 1st 2013.
S Favret, F Binet, E Lapalme, D Leboeuf, J Carbadillo, T Rubic, E Picard, G Mawambo, N Tetreault, JS Joyal, S Chemtob, F Sennlaub, JP SanGiovanni, M Guimond, P Sapieha. Deficiency in the Metabolite Receptor SUCNR1 (GPR91) Leads to Outer Retinal Lesions. Aging (Albany NY). 2013 Jun;5(6):427-44.
F Binet, G Mawambo, N Sitaras, N Tetreault, E Lapalme, S Favret, A Cerani, D Leboeuf, S Tremblay, F Rezende, A Juan, A Stahl, JS Joyal, É Milot, RJ. Kaufman, M Guimond, TE Kennedy, P Sapieha. Neuronal ER Stress Impedes Myeloid-cell Induced Vascular Regeneration Through IRE1α Degradation of Netrin-1. Cell Metabolism March 5th 2013. Featured in Highlights of Cell Metabolism
P Sapieha, J Chen, A Stahl, MR Seaward, TL Favazza, AM Juan, CJ Hatton, J-S Joyal, NM Krah, RJ Dennison, J Tang, TS Kern, JD Akula and LEH Smith. Omega-3 polyunsaturated fatty acids preserve retinal function in type 2 diabetic mice, Nutrition and Diabetes (2012) 2, doi:10.1038/nutd.2012.10.
Sapieha P. Eyeing Central Neurons in Vascular Growth and Reparative Angiogenesis. Blood June 15, 2012
JS Joyal, N Sitaras, F Binet, K Zaniolo, A Stahl, Z Shao, A Polosa, M Djavari, D Kunik, D Hamel, JCHonoré, JC Rivera, A Zabeida, D Varma, G Hickson, J Mancini, M Klagsbrun, S Costantino, C Beauséjour, P Lachapelle, L Smith, S Chemtob and P Sapieha. Neuron-Derived Semaphorin 3A Repulses Retinal Revascularization in a Mouse Model of Proliferative Retinopathies. Blood June 2011.
Sapieha P, Stahl A, Seaward M, Chen J, Krah N, Denission R, Connor KM, Gronert K & Willett K, Smith LE. 5-Lipoxygenase Mediates Anti-angiogenic Effects of ω-3 PUFAs on Proliferative Retinopathy. Science Translational Medicine. 2011 Feb 9;3(69):69ra12.
Sapieha P, Joyal J-S, Rivera JC, Kermorvant-Duchemin E, Sennlaub F, Hardy P, Lachapelle P, Chemtob S, Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life, Journal Clin Invest . 2010 Sep 1;120(9):3022-32
Sapieha P, Sirinyan M, Hamel H, Zaniolo K, Mamer O, Varma D, Joyal JS, Hardy H, Andelfinger G, Mitchell G, Sennlaub F, Chemtob S. The succinate receptor GPR91 of neurons plays a major role in retinal angiogenesis. Nature Medicine, Oct; 14(10):1067-76 2008.
Sapieha P, Peltier M, Manning W, Di Polo A. Fibroblast Growth Factor-2 Gene Delivery In Vivo Stimulates Axonal Regeneration of Adult Retinal Ganglion Cells After Acute Optic Nerve Injury. Molecular Cell Neuroscience, 2003 24: 656-672
- CIHR, Operating grant, 2010-2015
- Canadian Diabetes Association, Operating grant, 2011-2014
- Foundation Fighting Blindness, Canada, 2013-2016
- NSERC 2012-2017
- CHRP 2013-2016
- CQDM 2013-2015
- Alcon Research Institute New Investigator Award 2012
- Catherine Menard, Bourse d’excellence HMR.2012-2015
- Naoufal Akla, Bourse Suzanne Véronneau-Troutman, 2013-2016
- François Binet, FRSQ, 2010-2012
- Nicholas James Sitaras, CIHR, 2010-2011, FRSQ 2012-2015
- Agustin Cerani, FESP, 2010-2011, Reseau Vision 2012