Przemyslaw (Mike) Sapieha

Office Phone: 514-252-3400 ext. 7711
Fax: 514-252-3430
Lab Phone: 514-252-3400 ext. 7716
mike.sapieha@umontreal.ca

Research Axis  Vision Health
Research Unit  Neuro-vascular Ocular Diseases

TITLE

  • Associate Professor

EDUCATION

  • Postdoctorate,  2008-2010, Harvard Medical School
  • Postdoctorate,  2006-2008, McGill University
  • Ph.D., 2002-2005, Université de Montréal

DISTINCTIONS AND ACHIEVEMENTS

  • Wolfe Professorship in Translational Vision Research 2016
  • André Dupont Award 2015
  • Alcon Young Investigator Award 2012
  • Canada Research Chair  in Retinal Cell Biology 2010-
  • Canadian National Institute for the Blind New Researcher Award 2010
  • Charles A King Trust Postdoctoral Fellowship, 2009-2011
  • CIHR Postdoctotal Fellowship, 2009-2010
  • Foundation of Stars, Award of Excellence in Pediatric Research 2008
  • Fondation de la Recherche sur les Maladies Infantiles Postdoctoral Scholarship 2008
  • Heart and Stroke Foundation of Canada Research Fellowship Award 2006-2008
  • J.A. De Sève Award 2005

RESEARCH INTERESTS

Angiogenesis (the generation of new blood vessels from pre-existing ones) is a highly synchronized process requiring the coordinated efforts of several vascular and non-vascular cell populations and a stringent orchestration by the tissue being vascularized. Stereotyped angiogenesis is vital for both developmental growth and to restore tissue oxygenation and metabolic supply following vascular injury.

Given that angiogenesis becomes deregulated in numerous pathological contexts such as cancer and ischemic neuropathies, it is key to understand the molecular and cellular mechanism that ensure sound vessel growth. Our laboratory studies angiogenesis with a focus on ocular vascular systems. We tackle these diseases by studying vascular growth and the factors that regulate it. Moreover, we are interested in the cellular interactions and intracellular mechanisms that govern vessel growth in both physiological and pathological contexts.

Top

RESEARCH TEAM  

    • Agnieszka Dejda, Lab Manager
    • Norman Beaulieu, Research Associate
    • Francois Binet, Research Associate        
    • Karine Beauchemin, Research Assistant
    • Vera Guber, Research Assistant
    • Frédérique Pilon, Research Assistant
    • Ariel Wilson, Postdoctoral Fellow
    • Khalil Miloudi, Postdoctoral Fellow
    • Malika Oubaha, Postdoctoral Fellow
    • Célia Parinot, Postdoctoral Fellow                
    • Catherine Ménard, PhD Student
    • Gaelle Mawambo, PhD Student
    • Elisabeth Andriessen, PhD Student
    • Fréderic Fournier, MSc Student
    • Roberto Diaz, MSc Student
    • Flavio Rezende, Associate Clinical Professor-Clinical Associate

    WE ARE ALWAYS LOOKING FOR TALENTED AND MOTIVATED RESEARCHERS AT THE POSTDOC, PhD AND MSc LEVELS.

    Please send your CV to mike.sapieha@umontreal.ca

     

      Selected papers

      • Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy. Oubaha M, Miloudi K, Dejda A, Guber V, Mawambo G, Germain MA, Bourdel G, Popovic N, Rezende FA, Kaufman RJ, Mallette FA, Sapieha P .Sci Transl Med. 2016 Oct 26;8(362):362ra144.
      • Gut microbiota influences pathological angiogenesis in obesity-driven choroidal neovascularization. Andriessen EM, Wilson AM, Mawambo G, Dejda A, Miloudi K, Sennlaub F, Sapieha P. EMBO Mol Med. 2016 Dec 1;8(12):1366-1379. doi: 10.15252/emmm.201606531.
      • Truncated netrin-1 contributes to pathological vascular permeability in diabetic retinopathy. Miloudi K, Binet F, Wilson A, Cerani A, Oubaha M, Menard C, Henriques S, Mawambo G, Dejda A, Nguyen PT, Rezende FA, Bourgault S, Kennedy TE, Sapieha P. J Clin Invest. 2016 Aug 1;126(8):3006-22. doi: 10.1172/JCI84767.
      • MicroRNA signatures in vitreous humour and plasma of patients with exudative AMD. Ménard C, Rezende FA, Miloudi K, Wilson A, Tétreault N, Hardy P, SanGiovanni JP, De Guire V, Sapieha P. Oncotarget. 2016 Apr 12;7(15):19171-84. doi: 10.18632/oncotarget.8280.
      • ER Stress and Angiogenesis. Binet F, Sapieha P. Cell Metab. 2015 Oct 6;22(4):560-75. doi: 10.1016/j.cmet.2015.07.010. Review.
      • Neuropilin-1 mediates myeloid cell chemoattraction and influences retinal neuroimmune crosstalk. Dejda A, Mawambo G, Cerani A, Miloudi K, Shao Z, Daudelin JF, Boulet S, Oubaha M, Beaudoin F, Akla N, Henriques S, Menard C, Stahl A, Delisle JS, Rezende FA, Labrecque N, Sapieha P. J Clin Invest. 2014 Nov;124(11):4807-22. doi: 10.1172/JCI76492.
      • Neuron-derived semaphorin 3A is an early inducer of vascular permeability in diabetic retinopathy via neuropilin-1. Cerani A, Tetreault N, Menard C, Lapalme E, Patel C, Sitaras N, Beaudoin F, Leboeuf D, De Guire V, Binet F, Dejda A, Rezende FA, Miloudi K, Sapieha P. Cell Metab. 2013 Oct 1;18(4):505-18. doi: 10.1016/j.cmet.2013.09.003.
      • Neuronal ER stress impedes myeloid-cell-induced vascular regeneration through IRE1α degradation of netrin-1. Binet F, Mawambo G, Sitaras N, Tetreault N, Lapalme E, Favret S, Cerani A, Leboeuf D, Tremblay S, Rezende F, Juan AM, Stahl A, Joyal JS, Milot E, Kaufman RJ, Guimond M, Kennedy TE, Sapieha P. Cell Metab. 2013 Mar 5;17(3):353-71. doi: 10.1016/j.cmet.2013.02.003.
      • Eyeing central neurons in vascular growth and reparative angiogenesis. Sapieha P. Blood. 2012 Sep 13;120(11):2182-94. doi: 10.1182/blood-2012-04-396846. Review.
      • Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A. Joyal JS, Sitaras N, Binet F, Rivera JC, Stahl A, Zaniolo K, Shao Z, Polosa A, Zhu T, Hamel D, Djavari M, Kunik D, Honoré JC, Picard E, Zabeida A, Varma DR, Hickson G, Mancini J, Klagsbrun M, Costantino S, Beauséjour C, Lachapelle P, Smith LE, Chemtob S, Sapieha P. Blood. 2011 Jun 2;117(22):6024-35. doi: 10.1182/blood-2010-10-311589.

      Complete list of Dr. Sapieha's publications (PubMed)