Luigina Mollica

Office Phone: 514-252-3400 ext. 3404
Fax: 514-254-5094
Lab Phone: 514-252-3400 ext. 4658
lmollica.hmr@ssss.gouv.qc.ca

Research Axis  Immunology-Oncology
Research Unit  Transcriptional Regulation of Gene Expression

TITLE

  • Assistant Clinical Professor

EDUCATION

  • Ph.D., Pathology, Imperial College London, University of London (2006).
  • M.Sc. (Equivalency), Molecular Hematology, Imperial College London, University of London (2004). 
  • Postdoctorate, Medical Oncology, University of Montreal (2002).
  • Medical Specialist Certificate (two) Internal Medicine and Hematology, Collège des Médecins du Québec (2002).
  • Provincial medical license, Hematology, Collège des Médecins du Québec (2002).
  • Postdoctorate, Hematology, University of Montreal (2001).
  • Medical Specialist Certificate (three), Medical Oncology, Hematology, & Internal Medicine, Royal College of Physicians and Surgeons of Canada (2000).
  • Postdoctorate, Internal Medicine, University of Montreal (1999).
  • Federal medical license, Medicine, Medical council of Canada (1998).
  • M.D., Medicine, University of Montreal (1996).

DISTINCTIONS AND ACHIEVEMENTS

  • Young Investigator Award, British Society for Haemostasis and Thrombosis, 2005.
  • Young Investigator Award, International Society of Thrombosis and Haemostasis, 2005.
  • Clinician-Scientist Research Prize, University of Montreal, 2007. 

RESEARCH TEAM

  • Yves Paquette, Research Assistant

RESEARCH INTERESTS

Studies on molecular mechanisms that control gene expression of endothelial cells and Hematopoietic stem cells.

Selected papers

Lane D and Mollica L. Haemostatic gene polymorphisms in venous and arterial thrombosis. Pathophysiology of Haemostasis and Thrombosis 2002 Sep-Dec;32(5-6):213-5.

Raymond MA, Mollica L, Vigneault N, Désormeaux A, Chan JSD, Filep JG, and Hébert MJ.  Blockade of the apoptotic machinery by cyclosporin A redirects cell death towards necrosis in arterial endothelial cells: regulation by reactive oxygen species and cathepsin D.  FASEB Journal 2003 Mar;17(3):515-7.

Mollica L and Lane DA. Genetic studies in complex disease. Journal of Thrombosis and Haemostasis 2004 Feb;2(2):342-343.

Crawley JT, Lam JK, Rance JB, Mollica LR, O’Donnell JS and Lane DA. Proteolytic inactivation of ADAMTS13 by thrombin and plasmin. Blood 2005 Feb 1;105(3):1085-93

Mollica L, Preston RJS, Chion AC, Lees SJ, Collins P, Lewis S, and Lane DA. Autoantibodies to thrombin directed against both of its cryptic exosites. British Journal of Haematology 2006 Feb;132(4):487-93.

Almeida AM, Murakami Y, Layton MD, Hillmen P, Sellick GS, Richards S, Patterson S, Kotsianidis I, Mollica L, Crawford DH, Baker A, Ferguson M, Roberts I, Houlston R, Kinoshita, T, and Karadimitris A. Hypomorphic promoter mutation in the mannosyltransferase-encoding PIG-M gene causes inherited glycosylphosphatidyl-inositol deficiency. Nature Medicine 2006 Jul;12(7):846-51.

Mollica LR, Crawley JTB, Liu K, Wells DJ, Rance JB, Follow G, Landry JR, and Lane DA. Role of 5’ enhancer in the regulation of the human endothelial protein C receptor gene. Blood 2006 Aug 15;108(4):1251-9.

D’Angelo G, Mollica L, Hébert, J, Busque L. Clinical Hematology and Fundamentals of Hemostasis. Chapter 20: Myelodysplastic Disorders. Harmening DM, 5th Edidion, Baltimore, 2007

Bolduc V, Chagnon P, Provost S, Dubé MP, Belisle C, Gingras M, Mollica L, and Busque L. No evidence that skewing of X-inactivation patterns is transmitted to offspring in humans. The Journal of Clinical Investigation, 2008 Jan;118(1):333-41

Complete list of Dr. Mollica's publications (PubMed)

ADDITIONAL INFORMATION

Grants

  • Startup Grant, Maisonneuve-Rosemont Hospital Foundation.
  • Junior Clinical Investigator Grant 1 (Basic Research), FRSQ.
  • Startup Grant, FRSQ.
  • Operating Grant, Banting Research Foundation.

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