Mark Lesk

Office Phone: 514-252-3400 ext. 4959
Fax: 514-251-7094
Lab Phone: 514-252-3400 ext. 4957

Research Axis  Vision Health
Research Unit  Pathophysiological Mechanisms


  • Associate Professor


  • M.Sc., Weizmann Institute of Science, Israel (1984).
  • M.D., McGill University, Montreal (1989).
  • Ophtalmology, University of Montreal (1994).
  • Fellowship in glaucoma, Wills Eye Hospital, Philadelphia (1995).


  • Influence of blood flow and ocular biomechanics on the optic nerve in glaucoma;
  • Development of a new imaging device to measure the biomechanical properties of the optic nerve (patent application submitted);
  • Stem cell regeneration in glaucoma;
  • Blood flow deficiency in AMD.


  • Denise Descovich, MD
  • Kanwarpal Singh Chauhan, Ph.D. (co-direction Tsuneyuki Ozaki)
  • Jing Wang, MD, PhD student
  • Renaud Manuguerra-Gagne, Ph.D student (co-direction Denis Claude Roy)
  • Antoine Godin, Post-Doctoral Fellowship (co-direction Santiago Costantino)
  • Faeza Longhaba, MSc student
  • Olivier Fontaine,OD, Ph.D.student


selected papers

Hafez A, Bizzarro RLG, Rivard M, Lesk MR.  Changes in optic nerve head blood flow after therapeutic intraocular pressure reduction in glaucoma patients and ocular hypertensives.  Ophthalmology, 110(1):201-10, 2003.

Harasymowycz PJ, Kamdeu Fansi A, Papamatheakis DG,  Gresset J,  Lesk MR. Validity of screening for glaucomatous optic nerve damage using confocal scanning laser ophthalmoscopy (HRT II) in high risk populations: A Pilot Study.  Ophthalmology, 112(12) 2164-2171, 2005.

Hafez AS, Bizzarro R, Descovich D, Lesk MR. Correlation between finger blood flow and changes in optic nerve Head Blood Flow following Therapeutic Intraocular Pressure Reduction.  J Glaucoma, 14(6) 448-454, 2005.

Lesk MR, Hafez, AS., Descovich D. Relationship between Central Corneal Thickness and Changes of Optic Nerve Head Topography and Blood Flow After Intraocular Pressure Reduction in Open-angle Glaucoma and Ocular Hypertension. Arch Ophthalmol, 124 (11): 1568-1572, 2006.

B.C. Chauhan , F.S. Mikelberg , A.G. Balaszi , R.P. LeBlanc , M.R. Lesk , G.E. Trope, Canadian Glaucoma Study Group. Canadian Glaucoma Study: 2. risk factors for the progression of open-angle glaucoma. Arch Ophthalmol, Aug;126(8):1138-9,2008.

Hafez, A.S. Lesk, M.R. Ocular Techniques used for Measurement of Ocular Blood Flow. In Glaucoma, M. Sherwood R. Hitchings, J. Crowston, Shaarawy, E.(eds) Chapter 14, Elsevier Press, 2010.

Deschênes MC, Descovich D, Moreau M, Granger L, Kuchel GA, Mikkola TS, Fick GH, Chemtob S, Vaucher E, Lesk MR. Postmenopausal Hormone Therapy Increases Retinal Blood Flow and Protects the Retinal Nerve Fiber Layer. Invest Ophthalmol Vis Sci. 2010 May;51(5):2587-600.

Fontaine O, Olivier S, Descovich D, Cordahi G, Vaucher E, Lesk MR.  The Effect of Intravitreal Injection of Bevacizumab on Retinal Circulation in Patients with Neovascular Macular Degeneration. Invest Ophthalmol Vis Sci. 2011 Sep 22;52(10):7400-5.

Singh K, Dion C, Costantino S, Wajszilber M, Lesk MR, Ozaki T. Development of a novel instrument to measure the pulsatile movement of ocular tissues. Exp Eye Res. 2010 Jul;91(1):63-8.

Balwantray C. Chauhan Ph.D., Frederick S. Mikelberg, M.D., Paul H. Artes, Ph.D., A. Gordon Balazsi, M.D., Raymond P. LeBlanc, C.M., M.D., Mark R. Lesk, M.Sc., M.D., Marcelo T. Nicolela, M.D., Graham E. Trope, M.B., Ph.D.; for the Canadian Glaucoma Study Group.  The Canadian Glaucoma Study: 3. Impact of Risk Factors and Intraocular Pressure Reduction on the Rates of Visual Field Change.  Arch Ophthalmol. 2010 Oct;128(10):1249-55.

Complete list of Dr Lesk's publications (PubMed) 



  • Elvire Vaucher, EOUM


  • FRSQ Vision Health Network
  • Glaucoma Foundation San Francisco


  • Lesk, MR,  Wajszilber, M, et Ozaki, T. Apparatus and Method for Measuring a Biomechanical Property of an in vivo Eye, and Method of Diagnosis. World Wide Patent application, May, 2008.