Sylvie Lesage

Office Phone: 514-252-3400 ext. 4649
Fax: 514-252-3569
Lab Phone: 514-252-3400 ext. 4653
sylvie.lesage@gmail.com

Research Axis  Immunology-Oncology
Research Unit  Cellular Immunogenetics

TITLE

  • Associate Research Professor

EDUCATION

  • Senior Postdoctoral Internship with Dr. Marika Sarfati, University of Montreal (2002-2005).
  • Postdoctoral Internship with Dr. Christopher C. Goodnow, Australian National University (1999-2002).
  • Ph.D., Immunology (supervisor Dr. Patrice Hugo), McGill University (1995-1999).
  • B.Sc., Immunology, McGill University (1992-1995).

DISTINCTIONS AND ACHIEVEMENTS

  • CIHR, New Investigator Award (2010-2015)
  • Junior Investigator Level 1, FRSQ (2007-2011).
  • CIHR Senior Research Fellowship (2002-2007).
  • Postdoctoral Fellowship, CIHR (1999-2002).
  • Graduate Studies Award, FRSQ (1995-1999).

Research Interests

Our research goals are aimed at defining homeostatic regulation of cell populations composing the immune system and to identify their impact on the susceptibility of complex genetic diseases such as autoimmune diseases and cancer.

In particular, we study variations of T cell and dendritic cell sub-populations in various strains of mice. The ultimate goal is to increase our understanding of the cellular population dynamics in the immune system. This research will provide the basis for cellular therapy protocols aimed at restoring the immune balance to prevent the onset or abrogate the progression of various auto-immune diseases and lymphoid cancers.

Technologies: congenic and transgenic mice, cellular immunology, multiparametric flow cytometry, genetic association studies of polymorphisms.

Dr. Lesage and some of her students appear in the documentary movie on type 1 diabetes. www.sweet16film.com


 

RESEARCH Staff

Research Assistant:

  • Geneviève Chabot-Roy

Post-doctoral Fellows:

  • Gaëlle Chognard

Ph.D. Students:

  • Adam-Nicolas Pelletier, Université de Montréal scholar 
  • Roxanne Collin, Diabète Québec Scholarship

Revious graduate students:

Masters

  • Claudine Beauchamps, M.Sc., 2007
  • Marie Vilquin, Master II, 2009
  • Lisa Bellemare, M.Sc. 2012 

Ph.D.

  • Véronique Dugas, Ph.D.,2011
  • Fanny Guimont-desrochers, Ph.D., 2013
  • Erin Hillhouse, Ph.D., 2013  

sELECTED PAPERS

Hillhouse, E.E., Beauchamp, C., Chabot-Roy, G., Dugas, V., Lesage S. IL-10 limits the expansion of immunoregulatory CD4-CD8- T cells in autoimmune-prone NOD mice. 2010. Immuno Cell Biol. 88:771-780. Highlighted as “Outstanding Observation” by the journal.

Labrecque, N., Baldwin, T., Lesage, S. Molecular and genetic parameters defining T-cell clonal selection. 2011. Immuno Cell Biol. 89:16-26.

Guimont-Desrochers, F., Boucher, G., Dong, Z., Dupuis, M., Veillette, A., Lesage, S. Redefining interferon-producing killer dendritic cells as a novel intermediate in NK cell differentiation. 2012. Blood 119, 4349-4357. Highlighted as “Plenary Paper” by the journal. See also: Inside Blood, Zitvogel, L. & Housseau, F. Blood 119, 4345-4346 (2012).

Pelletier, A.N., Guimont-Desrochers, F., Ashton, M.P., Brodnicki, T. Lesage, S. The size of the plasmacytoid dendritic cell compartment is a multigenic trait dominated by a locus on mouse chromosome 7. 2012. J Immunol. 188, 5561-5570. Selected by Faculty of 1000: top 2% papers in the field.

Hillhouse, E.E., Lesage, S. A comprehensive review of the phenotype and function of antigen-specific immunoregulatory double negative T cells. 2013. J Autoimmun. 40, 58-65.

Pelletier, A.N., Lesage, S. The Idd13 congenic interval defines the number of merocytic dendritic cells, a novel trait associated with autoimmune diabetes susceptibility. 2013. Journal of Autoimmunity, DOI: 10.1016/j.jaut.2013.04.004.

Complete list of Dr Lesage's publications (PubMed)

ADDITIONAL INFORMATION

Funding

  • Natural Sciences and Engineering Council of Canada (NSERC)
  • Canadian Institutes of Health Research (CIHR)
  • Genome Canada
  • Canadian Diabetes Association (CDA)
  • Fonds québécois de la recherche sur la nature et les technologies (FQRNT)
  • Maisonneuve-Rosemont Hospital Foundation

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