Sylvie Lesage

TITLE

• Associate Professor

EDUCATION

• Senior Postdoctoral Internship with Dr. Marika Sarfati, University of Montreal (2002-2005).
• Postdoctoral Internship with Dr. Christopher C. Goodnow, Australian National University (1999-2002).
• Ph.D., Immunology (supervisor Dr. Patrice Hugo), McGill University (1995-1999).
• B.Sc., Immunology, McGill University (1992-1995).

DISTINCTIONS AND ACHIEVEMENTS

• CIHR, New Researcher (2010-2015)
• Junior Investigator Grant 1, FRSQ (2007-2011).
• CIHR Award (2002-2007).
• Postdoctoral Internship Grant, CIHR (1999-2002).
• Graduate Studies Award, FRSQ (1995-1999).

Research Interests

Our research goals are aimed at defining homeostatic regulation of cell populations composing the immune system and to identify their impact on the susceptibility of complex genetic diseases such as autoimmune diseases and cancer.

In particular, we study variations of T cell and dendritic cell sub-populations in various strains of mice. The ultimate goal is to increase our understanding of the cellular population dynamics in the immune system. This research will provide the basis for cellular therapy protocols aimed at restoring the immune balance to prevent the onset or abrogate the progression of various auto-immune diseases and lymphoid cancers.

Technologies: congenic and transgenic mice, cellular immunology, multiparametric flow cytometry, genetic association studies of polymorphisms

RESEARCH Staff

Research Associate:

• Maria De La Cruz Dominguez Punaro 

Research Assistant:

• Geneviève Chabot-Roy

Post-doctoral Fellows:

• Gaëlle Chognard
• Ramzan Muhammad

Ph.D. Students:

• Fanny Guimont-Desrochers, CIHR scholar, Canada Graduate Scholarship
• Erin E. Hillhouse, CIHR scholar, Canada Graduate Scholarship
• Adam-Nicolas Pelletier, Université de Montréal scholar 

M.Sc. Student:

• Lisa Bellemare,  Université de Montréal scholar 

B.Sc. Sudent:

• Roxanne Collin, Diabète Québec Scholarsphip

 

sELECTED PAPERS

Hillhouse, E.E., Beauchamp, C., Chabot-Roy, G., Dugas, V., Lesage S. IL-10 limits the expansion of immunoregulatory CD4-CD8- T cells in autoimmune-prone NOD mice. 2010. Immuno Cell Biol. doi:10.1038/icb.2010.84.

Dugas, V., Beauchamp, C., Chabot-Roy, G., Hillhouse, E.E., Lesage, S. Implication of the CD47 pathway in autoimmune diabetes. 2010. J Autoimmun. 35: 23-32.

Guimont-Desrochers, F., Z. J. Cappello, M. Chagnon, M. McDuffie, and S. Lesage. 2009. Cutting edge: Genetic characterization of IFN-producing killer dendritic cells. J Immunol 182:5193-5197

Guimont-Desrochers, F., C. Beauchamp, G. Chabot-Roy, V. Dugas, E. E. Hillhouse, J. Dusseault, G. Langlois, P. Gautier-Ethier, J. Darwiche, M. Sarfati, and S. Lesage. 2009. Absence of CD47 in vivo influences thymic dendritic cell subset proportions but not negative selection of thymocytes. Int Immunol 21:167-177.

Lesage, S., Van, V.Q., Bouguermouh, S., Gautier, P., Rubio, M., Levesque, M., Nguyen, S., Galibert, L., Sarfati, M. Expression of the self-marker CD47 on dendritic cells governs their trafficking to secondary lymphoid organs. 2006. EMBO J, 25:5560-5568.

Liston, A., Lesage, S., Gray, D.H.D., O’Reilly, L.A., Strasser, A., Fahrer, A.M., Boyd, R.L., Wilson, J., Baxter, A.G., Gallo, E.M., Crabtree, G.R., Peng, K., Wilson, S.R., Goodnow, C.C. Generalised resistance to thymic deletion in the NOD mouse: a polygenic trait characterized by defective induction of Bim. 2004. Immunity, 21:817-830.

Lesage, S., Hartley, S.B., Wilson, J., Goodnow, C.C. Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes. 2002. J. Exp. Med, 196: 1175-11.

Complete list of Dr Lesage's publications (PubMed)

ADDITIONAL INFORMATION

Funding

• Juvenile Diabetes Research Foundation International (JDRF)
• Natural Sciences and Engineering Council of Canada (NSERC)
• Fonds de la Recherche en Santé du Québec (FRSQ)
• Canadian Institutes of Health Research (CIHR)
• Maisonneuve-Rosemont Hospital Foundation

Top