Nathalie Labrecque
Office Phone: 514-252-3552
Fax: 514-252-7626
Lab Phone: 514-252-3400 ext.4643
nathalie.labrecque@umontreal.ca
Research Axis Immunology-Oncology
Research Unit Molecular Immunology
TITLE
- Associate Professor
EDUCATION
- Postdoctorate, IGBMC, France (1994-2000).
- Ph.D., IRCM, Montreal (1988-1994).
DISTINCTIONS AND ACHIEVEMENTS
- Senior Investigator Grant, FRSQ.
- New investigator, CIHR.
- Centennial Award, Medical Research Council of Canada.
RESEARCH TEAM
- Jean-François Daudelin, Research Assistant
- Paméla Thébault, Postdoctorate
- Salix Boulet, Postdoctorate
- Mélissa Mathieu, Ph.D. Student
- Audrey Gravot, Ph.D. Student
- Erin Fortier, Ph.D. Student
- Julien Sirois, M.Sc. Student
RESEARCH INTERESTS
Three principal research themes
- Study on memory T lymphocytes: identifying the cascade of molecular events required for memory T lymphocyte development and survival (project funded by the CIHR).
- Role of memory T lymphocytes in autoimmune processes: examining the role of memory T lymphocytes in the pathogenesis of autoimmune diabetes (project funded by JDRF).
- Study on the development of T lymphocytes in the thymus: determining the role of MAP kinases in thymic development of T lymphocytes (project funded by the NSERC).
For these studies, we are analyzing immune response and in vivo T lymphocyte development using transgenic and knockout mouse models.
The laboratory uses different molecular and cellular biology approaches such as cytometry, transgenesis and gene inactivation.
Selected papers
Ostiguy, V., Allard, È.-L., Marquis, M., Leignadier, J., Labrecque, N. 2006. IL-21 promotes T lymphocyte survival by activating the phosphatidylinositol-3-kinase signaling cascade. J.Leukoc.Biol. 82: 645-656..
Allard, È.-L., Hardy, M.-P., Leignadier, J., Marquis, M., Rooney, J., Lehoux, D., Labrecque, N. 2007. Overexpression of interleukin-21 promotes massive CD8+ memory T cell accumulation. Eur J.Immunol. 37:3069-3077.
Leignadier, J., Hardy, M.-P., Cloutier, M., Rooney, J., Labrecque, N. 2008. Memory T lymphocyte survival does not require T cell receptor expression. Proc. Natl. Acad. Sci USA 105:20440-20445.
Leignadier, J., Labrecque, N. 2010. Epitope density influences CD8+ memory T cell differentiation. Plos One, 5(10):e13740
Labrecque, N., Baldwin, T., Lesage S. 2011. The molecular and genetic parameters defining T cell clonal selection. Immunol Cell Biol, 89(1):16-26.
Leignadier, J., Rooney, J., Labrecque, N. 2011. Lowering TCR expression level on naïve CD8+ T cells does not affect memory T cell differentiation. Immunol Cell Biol, 89(2):322-5.
Rafei, M., Hardy, M.-P., Williams, P., Vanegas, J.R., Forner, K.-A., Dulude, G., Labrecque, N., Galipeau, J., Perreault, C. 2011. Development and function of innate polyclonal TCR??+ CD8+ thymocytes. J Immunol 187:3133-3144.
Mathieu, M., Labrecque N. 2011. Murine superficial lymph node surgery. JOVE, accepted.
Fortier, E.E., Rooney, J., Dardente, H., Hardy, M.P., Labrecque, N.*, Cermakian, N. 2011. Circadian variation of the response of T cells to antigen. J. Immunol., accepted.
Complete list of Dr Labrecque's publications (PubMed)
ADDITIONAL INFORMATION
Grants
- Role of the atypical MAP kinase ERK3 in T cell biology, NSERC, Discovery Grant, 2009-2014
- Identification of the molecular pathways controlling the development of functional CD8+ memory T cells, CIHR, Operating Grant, 2011-2016.
SUMMARY
- Immunology – Molecular Immunology