Josée Hébert

Office Phone: 514-252-3404
Fax: 514-254-5094
Lab Phone: 514-252-3400 # 3327
jhebert.hmr@ssss.gouv.qc.ca
www.bclq.org

Research Axis  Immunology-Oncology
Research Unit  Quebec Leukemia Cell Bank – Genetics of leukemias

TITLE

  • Hematologist and Cytogeneticist
  • Associate Professor, Department of Medicine, Université de Montréal
  • Director, Maisonneuve-Rosemont Hospital’s Cytogenetics Laboratory 
  • Director, Quebec Leukemia Cell Bank, CRHMR
  • Director, Cytogenetics Platform, IRIC-HMR
  • Holder of the Industrielle-Alliance Research Chair in leukemia (Université de Montréal) 

EDUCATION

  • M.D., Université de Montréal (1984).
  • Internal Medicine, Université de Montréal (1990).
  • Hematology, FRCP(c), Université de Montréal (1991).
  • INSERM U301 and Molecular Hematology Laboratory, St-Louis Hospital, Paris, (1992 to 1994).

RESEARCH INTERESTS

Our laboratory is part of the "Leucegene" group, a multidisciplinary team of translational research in leukemia which includes researchers at The Institute for Research in Immunology and Cancer (IRIC), clinician-researchers at HMR and researchers affiliated to Université Laval and McGill University.

The objectives of the Leucegene group are:

  • To improve the prognostic stratification of acute myeloid leukemia (AML) in order to offer an individualized risk-adapted therapy for AML patients therefore improving survival.
  • To identify new therapeutic targets in AML
  • To develop new therapies in this type of leukemia

We use experimental approaches including whole exome and transcriptome (RNA-seq) sequencing by next-generation sequencing and chemogenomics.

As part of this project, more than 500 well characterized and clinically annotated AML samples collected by the Leukemia Cell Bank of Quebec (www.bclq.org) will be analyzed. This project was funded by Genome-Canada through the 2012 competition in personalized medicine.

The cytogenetics platform of the BCLQ also offers standard and molecular cytogenetic analysis services for researchers. It is the only platform offering spectral karyotyping (SKY) for mouse and human samples in Quebec. With its unique expertise, our team has contributed to several research projects in the field of cancer genetics and DNA repair. Our group is also involved in the identification of new fusion genes in acute leukemia samples collected by the BCLQ using cytogenetics and molecular biology techniques.

RESEARCH TEAM

Administrative Coordinator

  • Claude Rondeau

Technical Coordinator

  • Sylvie Lavallée

Morphology and Immunophenotyping

  • Giovanni D'Angelo

Research Assistant

  • Miriam Marquis, Ph.D.

Professional Assistants

  • Marie-Claude Frenette
  • Annie Bilodeau
  • Julie Desrochers
  • Martine Lavoie 

Clinical Research Nurses

  • Suzanne Nadeau
  • Francine Habel

Databases

  • Cyrielle Beaubois (Data Manager)
  • Ginette Trottier (Administrative Assistant)

 

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Selected papers

Lavallée VP, Krosl J, Lemieux S, Boucher G, Gendron P, Pabst C, Boivin I, Marinier A, Guidos CJ, Meloche S, Hébert J, Sauvageau G. Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors. Blood. 2016 Mar 31. pii: blood-2016-03-705053. [Epub ahead of print]

Lavallée VP, Lemieux S, Boucher G, Gendron P, Boivin I, Armstrong RN, Sauvageau G, Hébert J. RNA-sequencing analysis of core binding factor AML identifies recurrent ZBTB7A mutations and defines RUNX1-CBFA2T3 fusion signature.  Blood. 2016 Mar 11. pii: blood-2016-03-703868. [Epub ahead of print]

Lavallée VP, Lemieux S, Boucher G, Gendron P, Boivin I, Girard S, Hébert J, Sauvageau G. Identification of MYC mutations in acute myeloid leukemias with NUP98-NSD1 translocations. Leukemia. 2016 Feb 9. doi: 10.1038/leu.2016.19. [Epub ahead of print] PubMed PMID: 26859078.

Pabst C, Bergeron A, Lavallée VP, Yeh J, Gendron P, Norddahl GL, Krosl J, Boivin I, Deneault E, Simard J, Imren S, Boucher G, Eppert K, Herold T, Bohlander SK, Humphries K, Lemieux S, Hébert J, Sauvageau G, Barabé F. GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential invivo. Blood. 2016 Feb 1. pii: blood-2015-11-683649. [Epub ahead of print] PubMed PMID: 26834243.

Lavallée VP, Baccelli I, Krosl J, Wilhelm B, Barabé F, Gendron P, Boucher G, Lemieux S, Marinier A, Méloche S, Hébert J, Sauvageau G.  The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias. Nature genetics. 2015. PubMed PMID: 26237430.

Lavallée VP, Gendron P, Lemieux S, D'Angelo G, Hébert J, Sauvageau G. EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations. Blood. 2015 Jan 1;125(1):140-3. 

Gerby B, Tremblay CS, Tremblay M, Rojas-Sutterlin S, Herblot S, Hébert J, Sauvageau G, Lemieux S, Lécuyer E, Veiga DF, Hoang T. SCL, LMO1 and Notch1 Reprogram Thymocytes into Self-Renewing Cells.PLoS Genet. 2014 Dec 18;10(12):e1004768.

Bordeleau ME, Aucagne R, Chagraoui J, Girard S, Mayotte N, Bonneil E, Thibault P, Pabst C, Bergeron A, Barabé F, Hébert J, Sauvageau M, Boutonnet C, Meloche S, Sauvageau G. UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity. Blood. 2014 Oct 9,124(15):2362-9.

Pabst C, Krosl J, Fares I, Boucher G, Ruel R, Marinier A, Lemieux S, Hébert J & Sauvageau G. Identification of small molecules that support human leukemia stem cell activity ex vivo. Nature Methods. 2014 Apr;11(4):436-42.

Yu H, Pak H, Hammond-Martel I, Ghram M, Rodrigue A, Daou S, Barbour H, Corbeil L, Hébert J, Drobetsky E, Masson JY, Di Noia JM, Affar el B. Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair.  Proc Natl Acad Sci U S A. 2014, Jan7;111(1):285-90.

Complete list of Dr. Hébert's publications since 2006 (PubMed)

ADDITIONAL INFORMATION

Grants

  • Cancer Research Network FRQS: 2011-2017.
  • COLE Foundation: 2010-2014 
  • Genome Canada: 2013-2017
  • The Terry Fox Research Institute: 2012-2014 

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