Janos Filep

Office Phone: 514-252-3400 ext. 4662
Fax: 514-252-3430
Lab Phone: 514-252-3400 ext. 3388
janos.g.filep@umontreal.ca
www.patho.umontreal.ca/jgfilepB.htm

Research Axis  Immunology-Oncology
Research Unit  Innate Immunity System (Inflammation) and Vascular Immunology

TITLE

  • Full Professor 

EDUCATION

  • Postdoctorate, Immunology, University of Montreal (1993). 
  • Postdoctorate, Pharmacology, University of Sherbrooke (1992). 
  • Postdoctorate, Pharmacology, Medizinische Hochschule, Hannover (1987). 
  • Postdoctorate, Pharmacology/Clinical Pharmacology, Fischer-Bosch Institute for Clinical Pharmacology, Stuttgart, Germany (1984). 
  • Fellowship in Physiology, Semmelweis University Medical School (1982). 
  • Radioisotopse in Medicine, Isotopes in Research and Medicine, Postgraduate Medical School, Budapest, Hungary (1980). 
  • General Medicine, Ministry of Health (1979). 
  • Blood Transfusion, Transfusion medicine, Postgraduate Medical School, Budapest, Hungary (1979). 
  • M.D., General Medicine, Semmelweis University Medical School (1978). 
  • M.Sc. (Equivalency ) Physiology, Semmelweis University Medical School (1978). 

DISTINCTIONS AND ACHIEVEMENTS

  • Six awards of excellence as a medical student for presentations in Physiology and Surgery given by the Rector of Semmelweis University School of Medicine and the Department of Health of the Government of Hungary, Budapest, Hungary (1975-1978).
  • Bosch Foundation Research Fellowship Award, Stuttgart, Germany (1982-1984).
  • Boehringer-Ingelheim Foundation Postdoctoral Fellowship Award, Stuttgart, Germany (1985-1987).       
  • Young Investigator Award, Hungarian Pharmacological Society (1988).
  • Distinguished Young Investigator Award, Hungarian Pharmacological Society (1989).
  • Fourth rank, Postdoctoral Award Competition, and Fellowship (1989-1993), Medical Research Council of Canada (1989).
  • Senior Investigator Grant, FRSQ (1993-1995).
  • Honorary Professorship, Albert Schweitzer International University, Geneva, Switzerland (2000).
  • Science and Peace Medal, Albert Schweitzer International University, Geneva, Switzerland (2003).
  • Recognition as one of the “Great Minds of the 21st Century” in Medical Research by the American Biographical Institute, Raleigh, NC, USA (2004).
  • Recognition as one of the “2000 Outstanding Intellectuals of the 21st Century” by the International Biographical Centre, Cambridge, England (2004). 

RESEARCH TEAM

  • Li Li Wang, Technician
  • Li Zhang, Technician
  • Driss El Kebir, Postdoctorate
  • Irina-Cristina Helici, M.Sc. (Co-direction)
  • Ying Zhang, Ph.D.

RESEARCH INTERESTS

  • Vascular immunology and inflammation;
  • Leukocytes and biology of endothelial cells;
  • Interactions between Leukocytes and endothelial cells;
  • Oxidative and peroxidative stress (peroxynitrite) and signaling; 
  • Endogenous anti-inflammatory molecules (aspirin-triggered lipoxin, antiflammin, annexin-1, etc);
  • Apoptosis;
  • Signaling through Toll-like receptors;
  • Cardiovascular diseases (coronary artery disease, septic shock);
  • Diabetic nephropathy. 

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Selected papers

Zouki C, Beauchamp M, Baron C, Filep JG. Prevention of in vitro neutrophil adhesion
to endothelial cells through shedding of L-selectin by C-reactive protein and peptides
derived from C-reactive protein
. J. Clin. Invest. 100:522-529, 1997.

Filep JG, Zouki C, Petasis NA, Hachicha M, Serhan CN. Anti-inflammatory actions of lipoxin A4 stable analogs are demonstrable in human whole blood: modulation of leukocyte adhesion molecules and inhibition of neutrophil-endothelial interactions. Blood 94:4132-4142, 1999.

Zouki C, Zhang SL, Chan JSD, Filep JG. Peroxynitrite induces integrin-dependent adhesion of human neutrophils to endothelial cells via activation of the Raf-1/MEK/Erk pathway. FASEB J. 15:25-27, 2001 (10.1096/fj.00-0521fje, published online November 9, 2000).

József L, Zouki C, Petasis NA, Serhan CN, Filep JG. Lipoxin A4 and aspirin-triggered 15-epi-LXA4 inhibit peroxynitrite formation, NF-κB and AP-1 activation, and IL-8 gene expression in human leukocytes. Proc. Natl. Acad. Sci. USA, 99:13266-13271, 2002.

Khreiss T, József L, Potempa LA, Filep JG. Conformational rearrangement in C-reactive protein is required for proinflammatory actions on human endothelial cells. Circulation 109:2016-2022, 2004.

József L, Khreiss T, Filep JG. CpG motifs in bacterial DNA delay apoptosis of neutrophil granulocytes. FASEB J. 18:1776-1778, 2004 (full paper: 10.1096/fj.04-2048fje published online September 2, 2004).

Khreiss T, József L, Potempa LA, Filep JG. Opposing effects of C-reactive protein isoforms on shear-induced neutrophil-platelet adhesion and neutrophil aggregation in whole blood. Circulation 110:2713-2720, 2004.

Khreiss T, József L, Potempa LA, Filep JGLoss of pentameric symmetry in C-reactive protein induces interleukin-8 secretion through peroxynitrite signaling in human neutrophils. Circ. Res., 97:690-697, 2005.

József L, Khreiss T, Filep JG. Activation of toll-like receptor-9 induces IL-8 secretion through peroxynitrite signaling in human neutrophils. J. Immunol., 176:1195-1202, 2006.

El Kebir D, József L, Khreiss T,  Pan W, Petasis NA, Serhan CN, Filep JG. Aspirin-triggered lipoxins override the apoptosis delaying action of serum amyloid A in human neutrophils. J Immunol 179:616-622, 2007. 

 Complete list of Dr Filep's publications (PubMed)

ADDITIONAL INFORMATION

Grants

  • CIHR; 2 operating grants(5 years) as principal investigator; and 1 operating grant (5 years) as Co-investigator.
  • CIHR-CNSF, China Joint Health Research Initiative; operating grant; Principal Investigator at the Canadian laboratory.
  • Quebec Foundation for Heart Disease; operating grant; Principal Investigator.
  • Kidney Foundation of Canada; operating grant; Co-investigator.

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