Lambert Busque

Office Phone: 514-252-3400 ext. 4674
Fax: 514-254-5094
Lab Phone: 514-252-3400 ext. 7738
lbusque.hmr@ssss.gouv.qc.ca

Research Axis  Immunology-Oncology
Research Unit  Hematopoiesis and Aging

TITLE

  • Associate Professor of Medicine

EDUCATION

  • M.D., Hematology, Molecular Biology (Harvard, Gary Gilliland).

RESEARCH INTERESTS

  • Detection of loci linked to telomere length determinants in blood cells by mapping and positional cloning;
  • Detection of quantitative trait loci (QTL) linked to the production of blood cells;
  • Role of causal mutations of myeloproliferative syndromes (JAK2) in the biology of telomeres. 

Selected papers

Jamal R., Bélisle C., Lessard M.-C., Hébert J., Roy D.-C., Levine R., Busque L. Evidence suggesting the presence of a stem cell clone anteceding the acquisition of the JAK2-V617F mutation. Leukemia. 2008 Jan 31.

Bolduc V., Chagnon P., Provost S., Dubé M.-P., Belisle C., Gingras M., Mollica L., Busque L. No evidence that skewing of X chromosome inactivation patterns is transmitted to offspring in humans. J Clin Invest. 2008 Jan;118(1):333-41.

Chagnon P., Schneider R., Hébert J., Fortin P.-R., Provost S., Belisle C., Gingras M., Bolduc V., Perreault C., Silverman E., Busque L. Identification and characterization of an Xp22.33;Yp11.2 translocation causing a triplication of several genes of the pseudoautosomal region 1 in an XX male patient with severe systemic lupus erythematosus. Arthritis Rheum. 2006 Apr;54(4):1270-8.

Levine R.-L., Belisle C., Wadleigh M., Zahrieh D., Lee S., Chagnon P., Gilliland D.-G., Busque L. X-inactivation-based clonality analysis and quantitative JAK2V617F assessment reveal a strong association between clonality and JAK2V617F in PV but not ET/MMM, and identifies a subset of JAK2V617F-negative ET and MMM patients with clonal hematopoiesis. Blood. 2006 May 15;107(10):4139-41. Epub 2006 Jan 24.

Chagnon P., Provost S., Belisle C., Bolduc V., Gingras M., Busque L. Age-associated skewing of X-inactivation ratios of blood cells in normal females: a candidate-gene analysis approach. Exp Hematol. 2005 Oct;33(10):1209-14.  

Complete list of Dr Busque's publications (PubMed)

ADDITIONAL INFORMATION

Grants

  • FRSQ

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